Chronic Pain

Hyperbaric oxygen therapy provides lasting chronic pain relief without opioids

Clinical studies show HBOT reduces central sensitization and outperforms standard pain medications for conditions like fibromyalgia, offering safe, drug-free pain management.
HBOT for Chronic Pain Relief | Bay Area Hyperbarics

Understanding chronic pain and why it persists

Chronic pain is pain that persists or recurs for more than three months, often continuing long after the original injury has healed. Unlike acute pain that serves a protective function, chronic pain results from complex changes in how the nervous system processes pain signals, a phenomenon known as central sensitization.

Conditions such as fibromyalgia, chronic back pain, arthritis, nerve damage and neuropathic disorders can all lead to chronic pain that significantly impacts physical function and emotional wellbeing. Traditional treatments including medication, physical therapy and nerve blocks may provide temporary relief but often fail to address the underlying neurological changes driving persistent pain. HBOT offers a different approach by targeting these root mechanisms directly.

  • Persistent pain lasting beyond normal tissue healing time

  • Heightened pain sensitivity and reduced pain tolerance

  • Fatigue, sleep disruption and cognitive difficulties

  • Reduced mobility, strength and daily functioning

Integration Illustration

How pressurized oxygen breaks the chronic pain cycle

HBOT addresses chronic pain through multiple neurological and biochemical pathways, providing relief that targets the root cause rather than masking symptoms.

Reduces central sensitization and pain hypersensitivity

Increases pain tolerance beyond standard medications

Restores brain activity in pain-processing regions

Releases natural pain-blocking chemicals

Provides opioid-free pain relief without side effects

Reduces inflammation driving persistent pain

For Providers

Clinical evidence for HBOT in chronic pain management

Hyperbaric oxygen therapy has demonstrated significant potential in managing chronic pain through multiple evidence-based mechanisms that address the neurological roots of persistent pain.

Central sensitization reduction: HBOT has shown the ability to reduce central sensitization, the amplified pain signaling in the central nervous system that underlies conditions like fibromyalgia. By modulating nociceptive processing and reducing neuronal hyperexcitability, HBOT addresses pain at its source rather than simply masking symptoms.

Superior outcomes vs. pharmacotherapy: A 2024 study published in Scientific Reports demonstrated that HBOT outperforms standard pharmacological treatments, specifically pregabalin and duloxetine, in fibromyalgia patients. Improvements were measured across physical, emotional and functional outcomes using Fibromyalgia Impact Questionnaire (FIQ) scores and pain thresholds. Results were particularly pronounced in patients with histories of childhood trauma, suggesting HBOT's neuroplastic effects may help resolve trauma-linked pain sensitization.

Neuroplasticity and brain activity restoration: HBOT increases metabolic activity in prefrontal and temporal brain regions that regulate pain processing. This enhanced brain activity correlates directly with symptom relief, suggesting that HBOT promotes neuroplastic changes that functionally restore impaired pain modulation pathways.

Endogenous opioid activation: Research from the University Health Network in Toronto has established that HBOT activates the body's natural pain control systems. It stimulates the release of nitric oxide and endogenous opioids, including dynorphin, which interact with specific receptors in the spinal cord and brain to inhibit pain signal transmission. This provides both short-term and longer-lasting pain relief without the side effects of exogenous opioid medications.

Clinical significance: HBOT should be considered as part of a comprehensive biopsychosocial approach to chronic pain management, emphasizing the central nervous system's role in chronic pain mechanisms. Its ability to provide effective pain relief while avoiding opioid dependency makes it a particularly valuable option in the current context of the opioid crisis.

Journal of Clinical Medicine

Hyperbaric Oxygen Therapy (HBOT) shows promise in managing chronic pain by targeting central sensitization in fibromyalgia.

Hyperbaric oxygen therapy (HBOT) has shown potential in managing chronic pain, particularly in conditions like fibromyalgia, by reducing central sensitization and improving symptoms. HBOT should be part of a comprehensive biopsychosocial approach to pain management, emphasizing the central nervous system's role in chronic pain mechanisms.

Hyperbaric Oxygen Therapy (HBOT) shows promise in managing chronic pain by targeting central sensitization in fibromyalgia.
Scientific Reports

HBOT outperforms traditional pharmacological treatments in fibromyalgia, particularly for patients with a history of childhood trauma.

Hyperbaric oxygen therapy (HBOT) offers significant advantages for managing fibromyalgia syndrome (FMS), particularly in patients with a history of childhood sexual abuse (CSA). Compared to standard pharmacological treatments (Pregabalin and Duloxetine), HBOT demonstrated superior improvements in physical, emotional, and functional outcomes, as measured by Fibromyalgia Impact Questionnaire (FIQ) scores, pain thresholds, and conditioned pain modulation. HBOT also increased brain activity in pre-frontal and temporal regions, correlating with symptom relief and suggesting a neuroplasticity effect. These findings underscore HBOT's potential as an effective therapeutic approach for chronic pain in FMS, with benefits extending beyond symptom reduction to neural functional restoration.

HBOT outperforms traditional pharmacological treatments in fibromyalgia, particularly for patients with a history of childhood trauma.

University Health Network Toronto

HBOT provides effective pain relief by stimulating natural painkillers and enhancing brain activity, offering a safe alternative to opioids.

HBOT has been shown to effectively reduce pain in animal models. It works by stimulating the release of natural pain-relieving chemicals in the body, including nitric oxide (NO) and endogenous opioids like dynorphin. These chemicals interact with specific receptors in the spinal cord and brain to block pain signals.


HBOT offers several advantages for chronic pain management. It taps into the body's natural pain control systems, providing both short-term and longer-lasting pain relief without the side effects of opioid drugs. HBOT may be a useful option, particularly for patients who do not respond well to or want to avoid long-term opioid medication.



HBOT provides effective pain relief by stimulating natural painkillers and enhancing brain activity, offering a safe alternative to opioids.
TESTIMONIALS

Patients share their pain relief stories

Lisa St John, the clinic director for Bay Area Hyperbarics, had chronic refractory osteomyelitis that lasted seven years with no relief. The infection induced severe fatigue and cognitive impairment that prevented her from working and required her to sleep up to 18 hours per day. Finally, a physician recommended hyperbaric oxygen therapy with antibiotics, which after 60 osteomyelitis treatments, healed her. Shortly after being healed, she sold her home to begin her first hyperbaric oxygen therapy clinic, which she has owned for 25 years!

Lisa, 44

Jennifer had osteomyelitis of the lower jaw (mandible), which proved difficult to heal. Her teeth were becoming loose, and her doctor thought she would need surgery. However, he prescribed hyperbaric oxygen therapy before the surgery, and after 60 osteomyelitis treatments, her chronic refractory osteomyelitis healed completely, regrowing bone in her mandible. Jennifer was able to keep her teeth, and was able to return to her active lifestyle, hiking regularly with her husband.

Jennifer, 68

How it works

Your path from chronic pain to lasting relief with HBOT

We design a personalized HBOT protocol based on your pain condition, history and treatment goals to maximize relief.

1

Comprehensive pain assessment and protocol design

Our medical team evaluates your pain history, current medications, previous treatments and functional limitations to create a targeted HBOT plan.

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2

Comfortable daily sessions in our pressurized chambers

You breathe 100% oxygen in a pressurized chamber for approximately 90 minutes per session. Treatment protocols typically involve 40 to 60 sessions.

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3

Progressive pain reduction and functional improvement

We track pain levels, mobility and daily functioning throughout treatment. Many patients report progressive improvement that continues after completing their protocol.

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Frequently Asked Questions

Answers to the questions patients ask most about hyperbaric oxygen therapy for chronic pain management and relief.

HBOT delivers oxygen under pressure that dissolves directly into blood plasma, reaching inflamed tissues and the central nervous system. It reduces central sensitization, which is the amplified pain signaling that makes chronic pain persist. HBOT also releases natural pain-blocking chemicals like endogenous opioids and nitric oxide, reduces neuroinflammation, and restores brain activity in regions that regulate pain processing.

Take the first step toward pain-free living

Schedule a free consultation to discuss how hyperbaric oxygen therapy can help you manage chronic pain without opioids and reclaim your quality of life.

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